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and methaemoglobinaemia makes the tissue hypoxia consequent on anaemia more severe, because methaemoglobin does not carry oxygen

However, azoles are less effective for aspergillosis or systemic yeast infections, and long-term use may result in hepatotoxicity, though they are generally better tolerated than polyenes ( ERG11 , reducing azole binding to the target enzyme (Lee et al., 2021)

It is not approved for human or animal consumption and must not be incorporated into food, drugs, supplements, or cosmetics

doi: 10.1128/CDLI.7.6.920-924.2000 32 TeskeyG.AbrahemR.CaoR.GyurjianK.IslamogluH.LuceroM.et al

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