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Candidate gene studies have identified a number of genes, such as catechol- O -methyltransferase ( COMT ), brain-derived neurotrophic factor ( BDNF ), neuregulin-1 ( NRG-1 ), and disrupted in schizophrenia ( DISC-1 ) that appear to be shared risk factors for schizophrenia, bipolar disorder, and MDD ( COMT , bipolar disorder has been associated with polymorphisms in a number of other genes coding for monoamine receptors, transporters, and synthetic and catabolic enzymes, including monoamine oxidase ( MAOA ), dopamine transporter ( DAT ), serotonin transporter ( 5HTT ), tryptophan hydroxylase ( TPH2 ), and the D2 , D4 , 5HT4 , and 5HT2A receptors ( 5HTT promoter has been linked with antidepressant-associated mania, lithium prophylactic efficacy, age of onset, and suicidality in bipolar illness ( A number of studies have found that the 66 Val/Met polymorphism of the BDNF gene, which has been associated with the regulation of neural resilience, plasticity, and proliferation, may be a risk gene for bipolar illness

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Despite these promising findings, BPC-157 is not without its limitations