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The intranasal pathway offers a unique opportunity to repurpose old drugs for new uses and to improve the efficacy of currently approved medications indicated for other administration routes [206]

The upregulated genes are involved in protein synthesis, phytohormone signaling, and responses to various stresses, while downregulated genes are associated with primary metabolism and developmental processes (Kumari et al., 2023)

In these cases, oral supplements may not be effectively absorbed, making B12 injections a more reliable treatment option

In this context, IONPs offer a means to achieve targeted iron overload in macrophages, a vital aspect given that both co-localization with the parasite and appropriate concentrations are crucial for their effectiveness

This is an electrophysiological test that can not only verify the diagnosis but may also help predict the outcome