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In accordance with suggested metabolic dysfunction, hypermethylation of a CpG site within DGKD, TRPC3, and two CpG sites within KCNB1 may contribute to abnormal insulin secretion

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Methylmalonic acid (MMA) and homocysteine levels: These metabolites accumulate when B12 is deficient and can help confirm diagnosis when serum B12 is borderline

The hypothesis that CYP2E1 modulates myocardial pathologies via mitochondrial biological processes was tested through transcriptomic and proteomic analyses using CYP2E1-specific animal models and stable H9c2 cell lines overexpressing Flag-CYP2E1 (Fig

Inhibition of polyamine degradation reduced senescence burden by 2035% in mammalian cells [114]