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doi: 10.1006/frne.2002.0229

Medication interactions may create supplementation needs

Individuals with risk factors for B12 deficiency including strict vegans, those with gastrointestinal conditions, patients taking long-term metformin or proton pump inhibitors, and older adultsshould discuss screening with their GP, even in the absence of obvious symptoms

Excess caffeine consumption increases urine production, leading to accelerated loss of these vital nutrients alongside essential minerals through increased urination

In normal epithelial cells and endothelial cells, extracellular matrix (ECM) detachment will destroy cell metabolic activity, increase the production of mitochondrial reactive oxygen species (ROS), enhance oxidative stress, and then cause anoikis (Fiocca 1988)