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4 Function of curcumin in the treatment of specific NDs 4.1 Alzheimers disease 4.1.1 Pathogenesis of AD Alzheimers disease (AD) is a progressive neurodegenerative disorder that accounts for 60%80% of all dementia cases worldwide

One rodent study involving sciatic nerve transection found that BPC 157 administration significantly improved functional recovery and nerve regeneration

Studies of PD-related genes in NSCs have suggested, have suggested that alteration of these genes are associated with the deregulation of proliferation, maintenance and differentiation (Le Grand et al., 2015)

Real-time quantitative PCR (RT-qPCR) The total RNA was extracted from leukocytes using the QIAamp RNA Blood Kit (Qiagen, Hilden, Germany), and cDNA was produced with the High-Capacity cDNA Reverse Transcription Kit (Thermo Fisher, Waltham, MA) as previously described 18

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