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After a closed head injury, ApoE / mice exhibit elevated levels of iron in their brains, suggesting that ApoE / deficiency may increase the risk of oxidative damage to hippocampal tissue ( In vitro studies show that upregulating sestrin2 decreases type I/II collagen and KEAP1 mRNA expression while increasing GPX4 and Nrf2 mRNA levels

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[DOI] [PMC free article] [PubMed] 40.Thornburg, J

If you are working through this transition, that conversation will give you helpful context for why supporting the gut is non-negotiable in any midlife MCAS plan