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The limitation in adipose expansion drives metabolic disease progression through multiple mechanisms

In the case of AN, it has been reported that hyperlipidemia occurs during refeeding and that l-carnitine administration improves the rapid decline in hematocrit [29]

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doi: 10.4049/jimmunol.1402944 14 IshiokaTKatayamaRKikuchiRNishimotoMTakadaSTakadaRet al

In terms of iron metabolism and homeostasis in immune cells, a study revealed that iron overload promotes abnormal differentiation of pathogenic T cells, including follicular helper T cells, by regulating DNA demethylation, thus exacerbating autoantibody production and the development of systemic lupus erythematosus (SLE) [26]