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The compound reduces pro-inflammatory cytokines (TNF-alpha and IL-6), limiting excessive tissue damage that prolongs recovery

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Doses above 4 mg per session are unusual and should be approached with extra care

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They tested these inhibitors in cell and animal models. They reported changes in intracellular nicotinamide-related metabolites and examined the biological effects of NNMT inhibition under experimental conditions. These outcomes have increased scientific interest in NNMT biology