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Prior to metabolism in the mitochondria, the acetyl group is transferred to coenzyme A (CoA) to form acetyl-CoA, which enters the TCA cycle to generate ATP through oxidative phosphorylation

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The increased ketone metabolism subsequently increased the regional ATP concentrations, showing HB as an alternative therapeutic substrate following TBI (62)

It is worth noting too that fat is a source of inflammation that has been linked to diabetes and other inflammatory diseases

HNF4-negative liver cancer lines are resistant to MCR To evaluate the possible functional impacts of altered SAA metabolism in mesenchymal liver cancer cell lines, we compared the responses of two mesenchymal liver cancer lines, SNU449 and SNU475, to methionine restriction with those of three epithelial cell lines Huh7, Hep3B, and HepG2