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Muscarinic receptor agonists and antagonists, in Goodman & gilman's pharmacological basis of therapeutics (New York: McGraw-Hill), 183200

Additionally, their metabolism can lead to inactivation and loss of biological activity, making their direct use limited 25

Finally, we propose combinations of these epigenetic modifiers according to different parameters, such as their source, mechanism of action, target and chemical structure

Variants in genes responsible for dopamine metabolism, synaptic function, and neuroinflammation have been identified as risk factors for Parkinson's disease

Additionally, epigenetic markings accumulate over time and contribute to both aging and the increased susceptibility to age-related diseases