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In particular, cellular detoxification by ABCC1 and ABCC2 is mediated through the efflux of metal ions such as mercury(Granitzer et al

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The activation of Akt results in skeletal muscle growth/maintenance since it controls the phosphorylation of a number of substrates involved in MPS including mTOR (and its downstream targets 4E-binding protein 1 (4E-BP1) and p70S6 kinase) and glycogen synthase kinase 3 (GSK3), as well as, the inhibition of protein degradation via the forkhead transcription factor (FOXO) pathway (Consitt et al., IGF-1, Exercise, and Effects on Muscle Metabolism As previously discussed, GH acts through its receptor

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