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however, their effects are modest 13,14 and did not support their further development for the management of obesity in the absence of diabetes

doi: 10.3389/fendo.2022.1037546 52

For both ingredients, a few universal principles apply: patch test before full-face use, introduce one active at a time, avoid combining with incompatible ingredients, and stop use if you experience persistent irritation, allergic reaction, or unexpected pigmentary change

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