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doi: 10.1080/1091367X.2024.2309169

ATM is activated by ATP depletion and modulates mitochondrial function through NRF1

The RNA binding protein CsrA controls c-di-GMP metabolism by directly regulating the expression of GGDEF proteins

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Research of novel drug treatments for diabetes has thus moved away from insulin analogs to new peptide hormones that have similar effects, in particular the incretin hormones, such as Glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and Dipeptidyl peptidase-4 (DPP-4), a key enzyme responsible for cleaving and inactivating both of GLP-1 and GIP peptides at the penultimate alanine residue ( GLP-1 is part of the peptide growth-factor family and activates a glucagon-type seven membrane-spanning G-protein coupled receptor