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This strongly suggests that earlyonset cases are more likely mediated by topdown mechanisms, driven by a stronger genetic/neurobiological vulnerability to central dysregulation

Rosenfeld RG, Pham H, Keller BT, Borchardt RT, Pardridge WM: Demonstration and structural comparison of receptors for insulin-like growth factor-I and -II (IGF-I and -II) in brain and bloodbrain barrier

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