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Low-fat diets show the strongest evidence, with a meta-analysis of intervention studies showing significant reductions in total testosterone, free testosterone, and dihydrotestosterone (DHT, a strong androgen and metabolite of testosterone), particularly pronounced in men following low-fat vegetarian diets (approx

However, oral supplements are limited by absorption variability and dose tolerance

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A patient-specific model identifies patients who could benefit from monotherapy and synergistic drug combinations We then employed the model to investigate the utility of monotherapy and combination treatments for individual patients based on the TCGA data