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However, myricetin is a high-risk PAINS compound

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Gilmartin, M.R., J.L

For instance, the methylation pattern of APOE was found to be of a bimodal structure, ranging from a hypomethylated CpG-poor promoter to a fully methylated 3-CpG-island [146]

This roughly represents a doubling of the absolute and relative number of deaths (1.4 million deaths from ASCVD, 11% of all deaths) compared to 1990 (Zhao et al., 2019)
