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Description
doi: 10.1136/openhrt-2018-001003 94
ACS Applied Materials & Interfaces
Phytomedicine Plus , 100633
Small molecules have been discovered or screened to bind to the different domains of TDP-43, such as the N-terminal domain, the RNA recognition motifs, or the C-terminal domain (33, 35)
In the phase 2b NATIVE trial (NCT03008070), 49% of patients receiving 1200 mg daily achieved NASH resolution without worsening fibrosis, compared to 27% with placebo, and 55% showed at least one-stage fibrosis improvement