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Studies in this systematic review support B12 supplementation for the treatment or prevention of metformin-induced deficiency and neuropathy, demonstrating increased levels of B12 and decreased serum homocysteine with supplementation

Importantly, treatment of DIO mice with our NNMT inhibitors did not impact food intake, but produced marked reductions in body weight, WAT mass, adipocyte size, and cholesterol levels with negligible toxicity or observable adverse effects