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ISBN 978-0-443-06839-3

By systematically reviewing and synthesizing existing literature, this article aims to provide insights for further investigation into ferroptosis mechanisms in OA and to broaden potential therapeutic targets and approaches for clinical management of ferroptosis-related pathological processes

Copper concentrations in the cerebellum also increased with age, but in AD mice, while copper levels did not significantly change (MannWhitney U , p = 0.063), significant changes in copper isotope ratios were observed (MannWhitney U , p = 0.016), with a notable enrichment in copper isotope ratios in AD transgenic mice (65Cu = 0.33) (81)

Bonferroni corrected p value 0.10)