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The observed bioenergetic disruptions align with mechanisms implicated in diabetic bone disease, supporting the relevance of this model in studying tissue-level responses that may also occur in vivo (Arajo et al

These biofilms can play an important role in infections as they protect pathogenic bacteria from antibacterial substances

On the other hand, EGCG was shown to effectively attenuate the activity of dihydrofolate reductase (DHFR) and disrupt the folate cycle, thereby diminishing the cellular production of nucleotides by damaging the one-carbon pool (237, 238)