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Localization of the Melanocortin-4 Receptor (Mc4-R) in Neuroendocrine and Autonomic Control-Circuits in the Brain

These records and histologic data were entered into a centralized database ( The following variables were compared among the three cohorts (NF1-associated, radiation-associated, and sporadic malignant peripheral nerve sheath tumor): NF1 status, age at diagnosis, gender, tumor location, tumor size, depth location, histologic subtype, and tumor grade (FNCLCC)

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It serves as the main route for glutamine metabolism in most tumors, with key regulatory enzymes including GLS and GLUD1 [153]

Also, it is important to note that synthetic retinoids, as well as high-dose vitamin A, may cause birth defects and should not be used orally or topically during pregnancy