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Histol Histopathol 12, 2

However, its predominant role is the removal of hydrogen peroxides by acting as a cofactor for the selenium-based enzyme family glutathione peroxidase (GPx), see Lu

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doi: 10.1007/s10529-014-1532-3 149 RatledgeC.StreekstraH.CohenZ.FichtaliJ

Examples of Bayesianbased study designs that incorporate both toxicity and efficacy include the EffTox design46 or TriCRM.47 It is also important to consider the PK/PD relationship in elucidating a biologically active dose range as supported by the task force on Methodology for the Development of Innovative Cancer Therapies.48 What else can be considered