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Toll-like receptor-mediated IRE1alpha activation as a therapeutic target for inflammatory arthritis

Cell Stem Cell 28 , 568580.e4 (2021)

IgweEORoodenrysSProbstYCdo RosarioVNetzelMEHongHTet al

Following further optimization in the PC activation process, for 1 M (62.5 g/ml) PC, the optimal thrombin concentration was 85 nM or 3.12 g/ml (8.5% molar ratio or 5% w/w ratio to PC), whereas higher thrombin concentrations did not result in higher APC generation (see Supplementary Fig

The first surgeries of the study have gone smoothly, 4 with plans to continue working with the FDA toward gaining approval to market SING-IMT in the United States