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W.KanogsunthornratJ.et al (2010a)

Unlike AMPARs and NMDARs, which drive the bulk of synaptic transmission, KARs are thought to play more specialized, modulatory functions in both the pre- and post-synaptic compartments where they control different forms of plasticity 1,4,5

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Methods In this phase 3a, double-blind, randomized, placebo-controlled trial conducted in 12 countries, we assigned adults with a body-mass index of 27 or more, a glycated hemoglobin level of 7 to 10%, and type 2 diabetes in a 3:1 ratio to receive once-weekly cagrilintide-semaglutide (2.4 mg each) or placebo, along with lifestyle intervention, for 68 weeks