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Moreover, their combined antioxidant, antiinflammatory and antiapoptotic action makes them a potentially effective cytoprotective team against UV-induced skin damage

For instance, in chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease, carnosine can significantly reduce the levels of TNF- and IL-6, thereby reducing inflammatory symptoms (73)

It acts as a signaling molecule that: Activates tissue repair pathways Stimulates collagen and glycosaminoglycan synthesis Promotes angiogenesis Modulates inflammation via NF-B suppression When endogenous levels fall, regenerative capacity falls in tandem

The indirect action is achieved by promoting the expression and activity of other antioxidant enzymes, such as GPX and TrxR