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Endogenous DNA Damage as a Source of Genomic Instability in Cancer

Note that this direct antioxidant action likely only occurs at certain concentrations

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The co-administration of cagrilintide and semaglutide leverages their complementary mechanisms for enhanced weight management and glycemic control, promoting significant reductions in bodyweight and improvements in metabolic health in populations with overweight, obesity, and type 2 diabetes 1-3

The expression of genes involved in the stress response (down-regulation of heat shock protein 70, hsp70 ), antioxidant defence (down-regulation of sod1, accompanied by up-regulation of sod2 ), and DNA repair (up-regulation of 8-oxoguanine DNA glycosylase) was significantly perturbed