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Figure 3 3.3 Metabolic pathways: microbial metabolites and pain modulation The gut microbiota is a major metabolic organ that produces many metabolites with diverse physiological effects (82)

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Tsang CK, Liu Y, Thomas J, Zhang Y, Zheng XF (2014) Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance

It is a signaling molecule with receptors distributed throughout the body, including in the heart