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Modulating the wnt signaling pathway with small molecules

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The fact that NRF2 is readily inducible in cultured astrocytes suggests that most pharmacological NRF2 activators may specifically target astrocytes in vivo, although there is still limited direct evidence for this

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Rnf43/Znrf3 are E3 ubiquitin ligases that are located on the plasma membrane and induce multiubiquitination of lysine

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