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IC/BPS patients have demonstrated distinct urine cytokine profiles compared with controls, which makes urine cytokines to be potential biomarkers for the diagnosis and mapping of the clinical characteristics of IC/BPS 11

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Likewise, TGF-1 suppressed the expression of GCLC (no effect on GCLM) and lowered GSH levels in rat hepatic stellate cells (HSCs), which facilitated fibrogenesis (Fu et al., 2008)