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The intrinsic metabolic environment of diabetes markedly exacerbates oxidative stress, and the accumulated polyunsaturated fatty acids within cardiomyocytes are highly susceptible to lipid peroxidation, leading to the excessive generation of 4-hydroxy-2-nonenal (4-HNE)

The heme was specifically increased in the herniated nucleus pulposus, which was consistent with the Hb analysis results and revealed pathological features of vasculogenesis in the herniated nucleus pulposus

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Martnez-Garca F, Novejarque A, Lanuza E (2007) Evolution of the amygdala in vertebrates