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Chem Biol 10:233239 Li F, Tang S-C (2017) Targeting metastatic breast cancer with ANG1005, a novel peptide-paclitaxel conjugate that crosses the blood-brain-barrier (BBB), vol 4

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5-Alpha Reductase Inhibitors (5-ARIs) (Examples: Finasteride, Dutasteride ) Action: Shrink the prostate over time by lowering DHT Onset: Slower 6 to 12 months Efficacy: Shrinks prostate by ~ 2025% Reduces risk of surgery or retention by ~50% (MTOPS trial) Side Effects: Decreased libido Erectile dysfunction Rare: breast tenderness or depression 3

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