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Peroxynitrite is believed to inhibit electron flow at CI, CIII, and minimally at CIV via direct interaction with the complexes (Poderoso et al., 2019)

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In a 4-years randomized trial involving eyes with moderate to severe non-proliferative diabetic retinopathy (NPDR) without center-involved diabetic macular edema (CI-DME), prophylactic intravitreal aflibercept (anti-VEGF) significantly reduced progression to proliferative diabetic retinopathy (PDR) or CI-DME ( Emerging biology highlights the importance of identifying upstream targets that contribute to the pathogenesis of DR

These differences contribute to variations in clinical behavior and are key factors in the development of precision therapies for individual patients [7]