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Lack of historical evidence to support folic acid exacerbation of the neuropathy caused by vitamin B12 deficiency

In some cases, adding folate improves neurologic symptoms when B12 alone does not

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In practical terms, a 95 kg person with 30% body fat who maintains a 400-calorie daily deficit might lose 5-6 kg total over 12 weeks through diet alone

This particular molecule has been synthesized to stop or limit the action of the NNMT enzyme (N-methyltransferase), which is involved in a series of biochemical reactions in the body, one of its main functions related to the metabolism of nicotinamide (a form of vitamin B3)