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This profile aligns with emerging interest in allosteric modulation as a strategy to fine-tune opioid receptor signaling while preserving spatial and temporal control by endogenous ligands

In this trial, once-weekly cagrilintide-semaglutide for 68 weeks in adults with overweight or obesity was highly effective and led to substantial and clinically meaningful weight loss, the authors concluded

doi: 10.1097/NEN.0000000000000176

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