ghk-cu tolerance or desensitization or loss of effectiveness long-term use GHK-Cu might be trending, but it's not new How GHK-Cu Tightens Loose Skin:
Description
Overt vitamin B6 deficiency is rare, but approximately 10 percent of Americans may have inadequate B6 status, and it often occurs with deficiencies in other B vitamins like folate and B12

de Castro Bras LE, Frangogiannis NG

Researchers have noted that an MTHFR mutation is a risk factor for hyperuricemia 7 in older men

Gastroenterology 156 (6), 16501660

Thats really good since its hard to loose the last 10
