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Mast cells in the gut can release histamine and add to that feeling

Individual response varies depending on severity and duration of deficiency

IGF-1-infused animals show lower vascular superoxide levels and higher levels of vascular eNOS and NO [64]

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Nat Rev Cancer 16:447462 Eriksson SE, Ceder S, Bykov VJN, Wiman KG (2019) p53 as a hub in cellular redox regulation and therapeutic target in cancer