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Summary Keywords critical care, vitamin D, vitamin C, medical nutrition therapy, micronutrients, review Citation Hill A, Starchl C, Dresen E, Stoppe C and Amrein K (2023) An update of the effects of vitamins D and C in critical illness

Bax protein is a proapoptotic member that acts by forming pores on the mitochondrial outer membrane, allowing cytochrome c to translocate into the cytoplasm, resulting in the loss of energy production and the activation of proteolytic cascade leading to apoptosis (Westphal et al., 2014)

The administration of cysteine-rich glutathione precursors, especially N-acetyl cysteine, has been shown to increase intracellular glutathione levels

The depletion of brain GSH has also been observed from both autopsies as well as in vivo MRS studies with aging and varied neurological disorders (Alzheimers disease, Parkinsons disease, etc.)

Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis