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It is important to note that few studies have examined omics biomarkers in relationship to existing clinical criteria, such as coma or a constellation of clinical and laboratory findings (i.e., Kings College Criteria) currently in use by clinical practitioners as a prognostic indicator

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Researchers commonly investigate: tissue repair pathways

Its also about biochemistry

In an extended view, in the homocysteine degradation process, NAD + is a cofactor of 5,10-methylenetetrahydrofolate reductase (MTHFR), which catalyzes the reduction of 5,10-methyleneTHF into 5-methyltetrahydrofolate [45]