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Importantly, GPX4, as a central regulator of ferroptosis, connects other cellular molecules and pathways with ferroptosis

This interdependence highlights that therapeutic strategies aimed at reverse remodeling may benefit from co-optimizing both pump function and drainage capacity

Cell Stress Chaperones 26 (1), 1518

But good quality human clinical trials of the combination are limited and the average effects seen for each on body composition are modest
