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Indeed there are scientific articles that propose that supporting NAD with niacinamide (vitamin B3) may be helpful for sickle cell disease

Oxford: Blackwell Science Publ

Although conventional hormone replacement normalizes biochemical parameters, many patients continue to experience neurocognitive impairment and affective symptoms, underscoring the complexity of thyroidbrain axis regulation

p53 Expression in rheumatoid and psoriatic arthritis synovial tissue and association with joint damage

Additionally, we show distinct differences in preservation mechanisms between sulfur amino acid vs H 2 S administration, despite similarities in required health-preserving pathways