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Nevertheless, evidence for substantial improvements in time-trial or maximum performance remains inconsistent [342]

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By leveraging the unique immunomodulatory properties of ferroptosis, pyroptosis, and necroptosis, and integrating these with existing immunotherapies, we can surmount current therapeutic resistance and achieve durable anti-tumor immunity

These findings suggest that exposure to environmental toxins like B[a]P can induce AhR activation through alteration of lncRNAs expression, which in turn has an influence on drug-metabolizing enzymes and affect drug responsiveness and toxicity