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The present study delved into the molecular mechanisms underlying OSA, emphasizing the role of A2AR in modulating these processes

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SQOR dynamically regulates H 2 S levels, keeping them within an optimal physiological range: on the one hand, genetic defects (e.g., in Leigh syndrome) or CoQ deficiency that abolish SQOR activity can cause toxic H 2 S accumulation, inhibiting the mitochondrial respiratory chain and leading to severe energy failure

10.1016/j.jgr.2020.02.004 66 RenJ

For example, the chemical MEHP was shown to negatively impact ovarian follicle by increasing the production of reactive oxygen species (ROS) and the level of oxidative stress, while simultaneously downregulating the expression of the enzymes glutathione peroxidase (GPx) and superoxide dismutase 1 (SOD1) (Wang et al., 2012)