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DCA promotes M2 polarization of tumor-associated macrophages (TAMs) in the TIME, enhancing tumor growth and immune evasion (36)

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Inflammatory cytokines adversely affect different components of the central nervous system (CNS) and peripheral nervous system (PNS), which may, in turn, lead to degeneration of neurons and microglial cells, increased BBB permeability, as well as prolonged levels of microglial activation, which impairs neurogenesis (36, 37)