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Pastore, et al., Clin

Systemic lupus erythematosus affects connective tissue and can strike any organ system of the body

For example, an RCT on moxonidine in the treatment of musculoskeletal pain showed no pain reduction compared with a placebo, illustrating the difficulties of managing pain via sympathetic modulation (Jewson et al., 2020)

Jain SK, Parsanathan R, Achari AE, Kanikarla-Marie P, Bocchini JA Jr

This, in turn, boosts metabolic rate and activates a gene known as sirtuin-1 (SIRT1), also referred to as the "longevity gene." SIRT1 is involved in reducing the risk of various conditions such as diabetes, obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.
