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Urinary aMT6s provides less resolution, but even with 4 h day time/waketime samples and 8 h/oversleep the calculated acrophase is within 30 min of that derived from hourly sampling (193)

Temozolomide nonresponsiveness in aggressive prolactinomas and carcinomas: management and outcomes

This is one of the most common culprits weve identified

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In that context, it is noteworthy that optimal function of stem cells depends on their highly specialized microenvironment, or niche [30, 31], and SASP factors deleteriously affect stem cells by altering this niche [32, 33]