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Synergism between metformin and analgesics/vitamin B12 in a model of painful diabetic neuropathy

Low levels of the nutrient are linked with fatigueso much so that some people with a B12 deficiency report feeling like theyre dying

In most cases, this depletion takes place 3 to 4 months after starting this therapy

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B12 supports mitochondrial function and cellular energy production through its role in fatty acid oxidation and the citric acid cycle