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It refers to the volume of plasma fluid that is cleared of drug per unit time (volume approach, L/hr or mL/hr) or the amount of the drug eliminated from the body per unit time (mass approach, mg/min or mg/hr)

OFT assesses an animal's exploratory and anxiety-like behaviors, and animals with FM-like symptoms often exhibit decreased exploratory behavior and increased anxiety-like behavior in these tests

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Its full agonism at 5-HT1A serotonin receptors and transient receptor potential vanilloid 1 (TRPV1) channel contributes to its anxiolytic and analgesic effects (Figure 2)

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