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It also plays a role in antiviral defence and tumour surveillance, contributing to balanced and resilient immune function

[DOI] [PubMed] [Google Scholar] 3.Gujral N, Freeman HJ, Thomson ABR

RNA silencing operates through two major mechanism: (i) Post-transcriptional gene silencing (PTGS) where Si RNAs or miRNAs direct sequence- specific mRNA degradation or translational repression, and (ii) Transcriptional gene silencing (TGS), which operates through RNA-directed DNA methylation (RdDM), histone modifications and chromatin remodeling
This plasticity has important implications for cancer immunotherapy, as it raises the possibility of redirecting Tpex cells toward a memory fate rather than simply reinvigorating them within the exhaustion program

Trihexyphenidyl and Benztropine are commonly used anticholinergic agents in clinical practice
