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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone

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Beyond that, degradation becomes measurable and progressive

Source: Prkacin et al., 2001 Multi-Organ Protection: Brain, Liver, Kidney, Lung The most comprehensive study came from Gojkovic et al

Clinical research demonstrated that AOD-9604 had no effect on serum IGF-1 levels, confirming that the peptide fragment does not activate the traditional growth hormone receptor pathway